KPV (10 mg) is a synthetic tripeptide (Lys-Pro-Val) derived from alpha-MSH, studied for NF-κB inflammatory signaling and mucosal inflammation research models. Third-party tested at 99% purity with a batch-specific COA. Ships across Canada. For research use only — not for human consumption.
KPV is a synthetic tripeptide research compound studied in laboratory settings for its role in anti-inflammatory and immunomodulatory signaling research. As the C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH), KPV is examined for its interaction with inflammatory pathway research models. Each vial from Central Peptides contains 10 mg of high-purity KPV, third-party verified and supplied with a batch-specific Certificate of Analysis (COA) for research use only. As one of the most studied melanocortin-derived peptide fragments, KPV remains a frequently requested compound among Canadian laboratories.
KPV Research Applications
KPV is a tripeptide — a chain of three amino acids — with the sequence Lys-Pro-Val (K-P-V). It corresponds to residues 11 to 13 at the C-terminus of alpha-MSH, a 13-amino-acid neuropeptide produced by the pituitary gland. Research reviews attribute much of the anti-inflammatory activity of alpha-MSH to this C-terminal KPV motif, which is one reason researchers study the isolated tripeptide rather than the full-length hormone.
A notable distinction is that KPV lacks the sequence motif required to bind known melanocortin receptors, so unlike full-length alpha-MSH it does not produce pigmentary effects. In controlled laboratory environments, researchers study KPV for its reported ability to enter intestinal cells via the PepT1 transporter and to modulate NF-κB signaling, a master regulator of inflammatory gene expression.
Common research areas where KPV is examined include:
NF-κB inflammatory signaling pathway research
Intestinal and epithelial inflammation models (e.g. colitis)
Melanocortin-derived peptide and alpha-MSH fragment research
Skin and mucosal inflammation research models
Purity and Quality Verification
Every batch of KPV sold by Central Peptides is manufactured under controlled synthesis and purification processes to ensure stability, consistency, and structural integrity for scientific research applications. Our compounds are independently tested and verified at 99% purity through High-Performance Liquid Chromatography (HPLC) and mass spectrometry.
Each order includes access to a batch-specific Certificate of Analysis, allowing researchers to verify identity, purity percentage, and testing details before use. This batch-level traceability is part of our commitment to transparency and quality control across our full research catalog. Researchers who require documented purity standards for their work can review the COA before and after purchase, ensuring every vial meets the same verified specification.
KPV is supplied as a lyophilized (freeze-dried) powder for maximum stability during shipping and storage. Lyophilization removes moisture from the compound, which helps preserve its structural integrity over time and allows it to remain stable during transit. For long-term integrity, store the lyophilized compound in a cool, dry environment away from light.
Once reconstituted for research, KPV is soluble in water (at 1 mg/mL or greater) and should be kept refrigerated at 2-8°C. To preserve compound integrity, aliquot the reconstituted material to avoid repeated freeze-thaw cycles, and use within an appropriate window to maintain consistency in research results.
Shipping Across Canada
Central Peptides ships KPV and all research compounds across Canada in discreet, temperature-conscious packaging. Orders are typically processed within 24 hours and delivered within 3 to 5 business days. Free delivery is available on qualifying orders over the threshold listed at checkout.
As a Canadian-based supplier, we offer domestic fulfillment, which means faster delivery times and fewer customs complications compared to ordering from international sources. Every shipment is packaged to protect the compound during transit and to maintain privacy.
Important Notice
This product is intended for laboratory research and scientific purposes only.
It is not approved by Health Canada, the FDA, or any other regulatory authority for human or veterinary use.
This product is not intended to diagnose, treat, cure, or prevent any disease.
By purchasing this product, customers acknowledge that it is strictly for research use only.
Buyers are responsible for conducting their own research and understanding the characteristics and intended use of this product prior to purchase.
For additional reference data on this compound, see PubChem: PubChem
Molecular Weight
342.43 g/mol
Chemical Formula
C₁₆H₂₄N₄O₄
Sequence Length
3 amino acids
Peptide Structure
Lys–Pro–Val
Appearance
White to off-white lyophilized powder
Purity
≥99% (HPLC)
Formulation
Lyophilized peptide powder, no additives
Solubility
Soluble in bacteriostatic water or sterile water for research preparation
Storage After Reconstitution
Store at 2–8 °C and use within 30 days
Stability During Shipping
Stable at room temperature for short periods due to lyophilization
